Fenaux P
Service des maladies du sang, CHU, Lille.
Rev Prat. 1993 Jun 1;43(11):1379-85.
Myelodysplastic syndromes are relatively frequent, with a distinct predominance in elderly subjects. They are characterized by a disorder of myeloid precursor cell maturation, which explains the presence of blood cytopenia responsible for clinical manifestations (anaemia, infection, haemorrhage). Beside cytopenia, the main risk is transformation into acute myeloid leukaemia. As a rule, these diseases are easily recognized by the conjunction of blood count and bone marrow aspirate. Apart from the intensive therapy prescribed for myelodysplastic syndromes in young subjects, treatments seldom have beneficial effects and are still symptomatic in most cases.
骨髓增生异常综合征相对常见，在老年患者中明显居多。其特征为髓系前体细胞成熟障碍，这解释了导致临床表现（贫血、感染、出血）的血细胞减少的存在。除血细胞减少外，主要风险是转化为急性髓系白血病。通常，通过血常规和骨髓穿刺检查相结合，这些疾病很容易被识别。除了为年轻患者的骨髓增生异常综合征规定的强化治疗外，治疗很少有有益效果，在大多数情况下仍为对症治疗。
