Lamb T M, Knecht A K, Smith W C, Stachel S E, Economides A N, Stahl N, Yancopolous G D, Harland R M
Department of Molecular and Cell Biology, University of California, Berkeley 94720.
Science. 1993 Oct 29;262(5134):713-8. doi: 10.1126/science.8235591.
The Spermann organizer induces neural tissue from dorsal ectoderm and dorsalizes lateral and ventral mesoderm in Xenopus. The secreted factor noggin, which is expressed in the organizer, can mimic the dorsalizing signal of the organizer. Data are presented showing that noggin directly induces neural tissue, that it induces neural tissue in the absence of dorsal mesoderm, and that it acts at the appropriate stage to be an endogenous neural inducing signal. Noggin induces cement glands and anterior brain markers, but not hindbrain or spinal cord markers. Thus, noggin has the expression pattern and activity expected of an endogenous neural inducer.
在非洲爪蟾中，施佩曼组织者可诱导背部外胚层形成神经组织，并使外侧和腹侧中胚层背化。组织者中表达的分泌因子头蛋白可模拟组织者的背化信号。本文给出的数据表明，头蛋白可直接诱导神经组织，在没有背部中胚层的情况下也能诱导神经组织，并且它在适当阶段发挥作用，是一种内源性神经诱导信号。头蛋白可诱导黏液腺和前脑标志物，但不能诱导后脑或脊髓标志物。因此，头蛋白具有内源性神经诱导剂所预期的表达模式和活性。
