Inoue T, Inoue T, Teshima T, Murayama S, Yamazaki H, Nose T, Tanaka E
Department of Radiation Oncology, Osaka University Medical School, Japan.
Strahlenther Onkol. 1995 Aug;171(8):475-7.
BACKGROUND/AIM: We already reported the tumor response during radiotherapy as a prognostic factor for T1 glottic carcinoma. In these reports, we did not evaluate the overall treatment time. There were many reports of correlation between local control and overall treatment time of radiation for head and neck cancer. Our aim was to evaluate the overall treatment time as a prognostic factor of the local control for T1 glottic carcinoma or not.
From 1967 through 1985, 295 patients of T1 glottic carcinoma were treated with telecobalt therapy at the Department of Radiology, Osaka University Medical School. Of 295 patients, 219 patients treated with 2 Gy per day were evaluated. The median of total doses was 60 Gy (42 to 72 Gy). Overall treatment times of patients with tumor clearance at 40 Gy were significantly shorter than those with tumor persistence at 40 Gy.
According to the univariate analysis, there were no statistically significant factors for local control except tumor response during treatment. Of 124 patients treated with a total dose of 60 Gy and the overall treatment time of 40 to 46 days, local control rates of patients treated with the overall treatment time of 40 to 42 days and 43 to 46 days were 88% and 78%, respectively (p = 0.3072). For 91 patients with tumor clearance at 40 Gy, local control rates of patients treated with the overall treatment time of 40 to 42 days and 43 to 46 days were 96% and 82%, respectively (p = 0.1645). Corresponding figures for 31 patients with tumor persistence at 40 Gy were 63% and 65%, respectively (p = 0.4227).
We compare the treatment results of patients treated with the same total dose and the same tumor response during radiotherapy. We concluded that the overall treatment time was not a prognostic factor for T1 glottic tumor treated with overall time of 40 to 46 days.
背景/目的：我们已经报道过放射治疗期间的肿瘤反应是T1期声门癌的一个预后因素。在这些报道中，我们没有评估总治疗时间。有许多关于头颈癌放疗局部控制与总治疗时间之间相关性的报道。我们的目的是评估总治疗时间是否为T1期声门癌局部控制的一个预后因素。
1967年至1985年期间，大阪大学医学院放射科对295例T1期声门癌患者进行了远距离钴治疗。在这295例患者中，对219例每天接受2 Gy治疗的患者进行了评估。总剂量的中位数为60 Gy（42至72 Gy）。40 Gy时肿瘤清除的患者的总治疗时间显著短于40 Gy时肿瘤持续存在的患者。
根据单因素分析，除治疗期间的肿瘤反应外，没有其他对局部控制有统计学显著意义的因素。在124例总剂量为60 Gy且总治疗时间为40至46天的患者中，总治疗时间为40至42天和43至46天的患者的局部控制率分别为88%和78%（p = 0.3072）。对于91例40 Gy时肿瘤清除的患者，总治疗时间为40至42天和43至46天的患者的局部控制率分别为96%和82%（p = 0.1645）。40 Gy时肿瘤持续存在的31例患者的相应数据分别为63%和65%（p = 0.4227）。
我们比较了放疗期间总剂量相同且肿瘤反应相同的患者的治疗结果。我们得出结论，对于总治疗时间为40至46天的T1期声门肿瘤，总治疗时间不是一个预后因素。
