口服茶碱诱发癫痫大发作。
Grand mal seizure induced by oral theophylline.
作者信息
Matthay R A, Matthay M A, Weinberger M M
出版信息
Thorax. 1976 Aug;31(4):470-1. doi: 10.1136/thx.31.4.470.
Abstract
A grand mal convulsion occurred in a patient with decompensated cor pulmonale. Although only modest doses of oral theophylline were being administered at the time of the convulsion the serum theophylline level was markedly raised and the theophylline clearance was very low. After treatment for cor pulmonale theophylline clearance improved; however, with the subsequent onset of fever and pneumonia the clearance decreased again, illustrating the potential lability of theophylline clearance.
摘要
一名肺心病失代偿期患者发生了癫痫大发作。尽管在发作时仅给予了适量的口服茶碱，但血清茶碱水平显著升高，且茶碱清除率非常低。在治疗肺心病后，茶碱清除率有所改善；然而，随后发热和肺炎发作时，清除率再次下降，这说明了茶碱清除率可能具有不稳定性。
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Grand mal seizure induced by oral theophylline.口服茶碱诱发癫痫大发作。
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本文引用的文献
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Pharmacokinetics of theophylline. Application to adjustment of the clinical dose of aminophylline.茶碱的药代动力学。在氨茶碱临床剂量调整中的应用。
Clin Pharmacol Ther. 1972 May-Jun;13(3):349-60. doi: 10.1002/cpt1972133349.
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Editorial: Rational use of theophylline for bronchodilatation.社论：茶碱在支气管扩张中的合理应用。
N Engl J Med. 1974 Jul 18;291(3):151-3. doi: 10.1056/NEJM197407182910310.
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Rational intravenous doses of theophylline.氨茶碱的合理静脉给药剂量。
N Engl J Med. 1973 Sep 20;289(12):600-3. doi: 10.1056/NEJM197309202891202.
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Effects of etiocholanolone-induced fever on plasma antipyrine half-lives and metabolic clearance.表雄酮诱导的发热对血浆安替比林半衰期及代谢清除率的影响。
Clin Pharmacol Ther. 1975 Apr;17(4):447-57. doi: 10.1002/cpt1975174447.
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Theophylline-induced seizures in adults. Correlation with serum concentrations.
Ann Intern Med. 1975 Jun;82(6):784-7. doi: 10.7326/0003-4819-82-6-784.
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