肺心病患者茶碱清除率受损。
Impaired theophylline clearance in patients with cor pulmonale.
作者信息
Vicuna N, McNay J L, Ludden T M, Schwertner H
出版信息
Br J Clin Pharmacol. 1979 Jan;7(1):33-7. doi: 10.1111/j.1365-2125.1979.tb00893.x.
Abstract
1 The relationship between serum theophylline concentration and daily dose was studied in 45 patients receiving aminophylline orally and in 36 patients receiving it by constant intravenous infusion. 2 Patients were categorized as uncomplicated chronic obstructive pulmonary disease (COPD) or COPD with cor pulmonale (CP). 3 Serum theophylline concentration relative to daily theophylline dose was significantly higher in patients with COPD plus CP than in patients with COPD alone. 4 Total body clearance of theophylline estimated from data obtained during constant intravenous infusion was significantly lower in COPD plus CP than in patients with COPD alone. 5 We conclude that reduced maintenance doses of theophylline are indicated in patients with COPD when complicated with CP.
摘要
- 对45例口服氨茶碱的患者和36例持续静脉输注氨茶碱的患者，研究了血清茶碱浓度与日剂量之间的关系。2. 患者被分为单纯慢性阻塞性肺疾病（COPD）或合并肺心病（CP）的COPD。3. 合并CP的COPD患者相对于每日茶碱剂量的血清茶碱浓度显著高于单纯COPD患者。4. 根据持续静脉输注期间获得的数据估算的茶碱全身清除率，合并CP的COPD患者显著低于单纯COPD患者。5. 我们得出结论，COPD合并CP的患者需要降低茶碱维持剂量。
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