[阿尔茨海默病痴呆家系的连锁分析]
[Linkage analysis in pedigrees with Alzheimer's dementia].
作者信息
Mazura I, Jirák R, Koukolík F
机构信息
Psychiatrické centrum Praha.
出版信息
Vnitr Lek. 1993 Oct;39(10):951-3.
PMID:8236867
Abstract
Linkage analysis with three specific DNA markers was carried out on the Alzheimer's dementia pedigrees. The DNA markers used in our study, D21S1/D21S11, D21S13 and D21S16 in the 21q11.2-21q21 regions are localized. The results from different brain DNA samples and from peripheral blood samples of AD families were evaluated by two-point linkage analysis. The linkage between DNA markers and one AD pedigree was observed (D21S1/S11 and D21S13).
摘要
对阿尔茨海默病痴呆家系进行了与三种特定DNA标记的连锁分析。我们研究中使用的DNA标记，即位于21q11.2 - 21q21区域的D21S1/D21S11、D21S13和D21S16，已被定位。通过两点连锁分析评估了来自不同脑DNA样本和AD家族外周血样本的结果。观察到DNA标记与一个AD家系之间存在连锁关系（D21S1/S11和D21S13）。
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