Wijsman E M
Division of Medical Genetics, University of Washington, Seattle 98195.
Genet Epidemiol. 1993;10(6):349-60. doi: 10.1002/gepi.1370100604.
Participants in the Alzheimer's disease component of GAW8 had access to three collections of pedigrees, complete with marker data from chromosomes 19 and 21. There were a total of 94 independent pedigrees and more than 2,000 individuals. Onset of the disorder varied widely among pedigrees. These data are briefly summarized along with a discussion of the problems associated with performing genetic analyses of Alzheimer's disease. The majority of the workshop participants performed an analysis either with some of the data contributed to the workshop or with data simulated on pedigrees of the same structure and disease status as were contributed. There were also a few purely methodological contributions. The contributions are summarized in three general areas: family association and phenotype, linkage analysis, and heterogeneity tests.
GAW8中阿尔茨海默病部分的参与者可以获取三个家系集合，以及来自19号和21号染色体的标记数据。总共有94个独立家系和2000多名个体。该疾病的发病在各个家系中差异很大。这些数据将被简要总结，并讨论与进行阿尔茨海默病基因分析相关的问题。大多数研讨会参与者使用为研讨会提供的部分数据或在与所提供的结构和疾病状态相同的家系上模拟的数据进行了分析。也有一些纯粹的方法学贡献。这些贡献总结在三个一般领域：家系关联与表型、连锁分析和异质性检验。
