Likhachev A Ia, Ivanov-Golitsyn M N
Vopr Onkol. 1976;22(6):44-7.
The experiments on mice of line SHR have shown that in animals, delivered by Cesarean section I hour following intrauterine injection of 40 mg/Kg of DMBA in mothers (a period of maximum concentration of the carcinogen in the tissues of foetuses) and sacrificed one year later, carcinogenesis proceeded much more intensively than in mice, which after transplacental DMBA exposure continued their intrauterine development for 6 hours longer, i.e. till complete disintegration of DMBA. An enhancement of the transplacental carcinogenic effect was manifested in a reliable increase of the total frequency of the appearance of different neoplasms, in more frequent development of lung, ovary and mammary tumors, and also in the appearance of malignant lung tumors-adenocarcinomas. A considerable enhancement of the transplacental blastomogenic effect in these mice was due to exclusion of the detoxication function of the maternal organism.
对SHR品系小鼠的实验表明，在母鼠子宫内注射40mg/Kg的DMBA后1小时进行剖宫产（这是胎儿组织中致癌物浓度最高的时期），并在一年后处死动物，与经胎盘接触DMBA后在子宫内继续发育6小时更长时间（即直到DMBA完全分解）的小鼠相比，这些小鼠的致癌过程要强烈得多。经胎盘致癌作用的增强表现为不同肿瘤出现的总频率可靠增加，肺、卵巢和乳腺肿瘤的发生更为频繁，还表现为恶性肺肿瘤——腺癌的出现。这些小鼠经胎盘致瘤作用的显著增强是由于母体解毒功能的排除。
