Perasso A, Testino G, Ansaldi F
Department of Gastroenterology and Digestive Endoscopy, San Martino Hospital, Genova, Italy.
Acta Gastroenterol Latinoam. 1993;23(1):5-11.
Chief cell mass and serum Pepsinogen I were calculated in 25 duodenal ulcer patients and in 40 healthy controls. Comparisons were also made with parietal cell mass and the stimulated acid secretion. Chief cell mass was expressed bay a Zymogenous Index (ZI) obtained by multiplying the number of chief cells per mm2 for the thickness of the glandular layer. The analysis of the data shows a significant decrease of ZI in duodenal ulcer patients in comparison with controls. The grouping of the subjects according to the age (over and under fifty years), confirms that ZI decreases significantly in duodenal ulcer groups in relation with the respective groups of control. In case of duodenal ulcer with fundic superficial gastritis no behavioural changes of ZI are observed in comparison to those affected by duodenal ulcer with normal fundic mucosa. The serum Pepsinogen I significantly increases in duodenal ulcer patients in comparison to the controls, either in the subjects over and under fifty. In the group of duodenal ulcer patients with superficial fundic gastritis a significant increase of serum Pepsinogen I can be pointed out in comparison to the ulcer patients with normal fundic mucosa. The grouping of the patients on the basis of hyperparietalism and normoparietalism has shown in the former group hypozymogenism and in the latter normozymogenism. Finally, no correlation has emerged between Zymogenous Index and serum Pepsinogen I.
对25例十二指肠溃疡患者和40例健康对照者计算主细胞量和血清胃蛋白酶原I。还将其与壁细胞量和刺激后的胃酸分泌进行了比较。主细胞量用酶原指数（ZI）表示，该指数通过每平方毫米主细胞数量乘以腺层厚度获得。数据分析显示，与对照组相比，十二指肠溃疡患者的ZI显著降低。根据年龄（50岁以上和50岁以下）对受试者进行分组，结果证实，十二指肠溃疡组的ZI相对于各自的对照组显著降低。与胃底黏膜正常的十二指肠溃疡患者相比，胃底浅表性胃炎的十二指肠溃疡患者未观察到ZI的行为变化。与对照组相比，十二指肠溃疡患者的血清胃蛋白酶原I显著升高，50岁以上和50岁以下的受试者均如此。与胃底黏膜正常的溃疡患者相比，胃底浅表性胃炎的十二指肠溃疡患者组血清胃蛋白酶原I显著升高。根据胃酸分泌过多和正常胃酸分泌对患者进行分组，结果显示前一组存在酶原生成减少，后一组存在酶原生成正常。最后，酶原指数与血清胃蛋白酶原I之间未发现相关性。
