Perasso A, Testino G, de Angelis P, de Grandi R, Augeri C
Divisione di Gastroenterologia ed Endoscopia Digestiva, Ospedale San Martino, Genova, Italy.
Gastroenterol Clin Biol. 1990;14(2):158-62.
In the present study, a counting method for the evaluation of chief cell mass was proposed, based on the assessment of a zymogenous index (ZI) obtained by multiplying the number of cells/mm2 by the thickness of the glandular layer. Results obtained in 40 subjects with normal gastric mucosa did not show significant ZI differences between sexes. A statistically significant decrease in ZI was observed in patients above age 50, thus being directly related to the significant decrease in the thickness of the glandular parenchyma and in the number of chief cells/mm2 observed in this age group. The data obtained were in agreement with the pattern of change observed for serum pepsinogen I (PG I) whose values were related to the chief cell mass in connection with sex and age of the subjects.
在本研究中，基于对通过将每平方毫米细胞数乘以腺层厚度获得的酶原指数（ZI）的评估，提出了一种评估主细胞量的计数方法。在40例正常胃黏膜受试者中获得的结果显示，性别之间的ZI没有显著差异。在50岁以上的患者中观察到ZI有统计学意义的下降，这与该年龄组中观察到的腺实质厚度和每平方毫米主细胞数量的显著下降直接相关。获得的数据与观察到的血清胃蛋白酶原I（PG I）的变化模式一致，其值与受试者的性别和年龄相关的主细胞量有关。
