Tommerup L J, Raab D M, Crenshaw T D, Smith E L
Biogerontology Laboratory, University of Wisconsin-Madison.
J Bone Miner Res. 1993 Sep;8(9):1053-8. doi: 10.1002/jbmr.5650080905.
It was previously reported that weight-bearing exercise increases femur periosteal formation in 3-year-old, 230 kg cross-bred sows. To determine if this weight-bearing exercise also stimulated non-weight-bearing bone, bone formation in the seventh rib from these same sows was measured histomorphometrically on the periosteal, endocortical, and osteonal envelopes. The sows were randomly assigned by body weight to basal (B, n = 6), control (C, n = 7), or trained (T, n = 7) groups. After 3 weeks of exercise adaptation, T walked on a treadmill for 17 weeks at 5 km/h, 20 minutes/day, 5 days/week, at 5% grade. Groups were sacrificed initially (B) or after 20 weeks (C and T). Periosteal mineral apposition rate (MAR) was calculated over 136 days. Osteonal and endocortical MAR were calculated over the 14 days prior to sacrifice. There were no effects of exercise on the periosteal or endocortical percentage double-labeled surface (dLS/BS), osteonal remodeling frequency (N.dL.On/B.Ar), or MAR in any bone envelope of the rib. In conclusion, weight-bearing exercise sufficient to stimulate periosteal formation in the femur did not activate formation in the rib. Bone response to weight-bearing exercise appears to be specific to the loaded bones.
先前有报道称，负重运动可增加3岁、体重230千克的杂交母猪股骨骨膜的形成。为了确定这种负重运动是否也能刺激非负重骨骼，对这些母猪第七肋骨的骨膜、骨内膜和骨单位包膜的骨形成进行了组织形态计量学测量。根据体重将母猪随机分为基础组（B，n = 6）、对照组（C，n = 7）或训练组（T，n = 7）。经过3周的运动适应期后，训练组的母猪以5千米/小时的速度在跑步机上行走17周，每天20分钟，每周5天，坡度为5%。最初处死基础组（B），20周后处死对照组（C）和训练组（T）。计算136天内的骨膜矿物质沉积率（MAR）。计算处死前14天内的骨单位和骨内膜MAR。运动对肋骨任何骨包膜的骨膜或骨内膜双标记表面百分比（dLS/BS）、骨单位重塑频率（N.dL.On/B.Ar）或MAR均无影响。总之，足以刺激股骨骨膜形成的负重运动并未激活肋骨的骨形成。骨骼对负重运动的反应似乎特定于负重的骨骼。
