Nissinen A, Tervahauta M, Pekkanen J, Kivinen P, Stengård J, Kaarsalo E, Kivelä S L, Väisänen S, Salonen J T, Tuomilehto J
Department of Community Health and General Practice, University of Kuopio, Finland.
Age Ageing. 1993 Sep;22(5):365-76. doi: 10.1093/ageing/22.5.365.
In a 30-year follow-up survey of the Finnish cohorts of the Seven Countries Study in 1989, 470 men aged 70-89 years were examined in two rural areas of Finland, in the East and in the West. Life-style-related coronary heart disease risk factors were at high levels in both groups, but the difference between areas found in the same cohort in middle age had mostly disappeared or partially reversed. Mean levels of systolic/diastolic blood pressure, body mass index, fasting blood glucose, blood glucose after 2-hour oral glucose tolerance test, and plasma fibrinogen were higher in the West than in the East (p < or = 0.05), but serum thiocyanate which reflects smoking habits was higher in the East (p < 0.001). No significant differences between areas were found in mean levels of serum total cholesterol, LDL-cholesterol, HDL-cholesterol, triglycerides, apolipoprotein A-I, apolipoprotein B, lipoprotein (a), plasma coagulation factor VIIc, and prevalence of current smoking.
在1989年对七国研究中的芬兰队列进行的一项30年随访调查中，对芬兰东部和西部两个农村地区的470名70 - 89岁男性进行了检查。与生活方式相关的冠心病危险因素在两组中都处于较高水平，但中年时在同一队列中发现的地区差异大多已消失或部分逆转。西部的收缩压/舒张压平均水平、体重指数、空腹血糖、口服葡萄糖耐量试验2小时后血糖以及血浆纤维蛋白原均高于东部（p≤0.05），但反映吸烟习惯的血清硫氰酸盐在东部较高（p < 0.001）。在血清总胆固醇、低密度脂蛋白胆固醇、高密度脂蛋白胆固醇、甘油三酯、载脂蛋白A-I、载脂蛋白B、脂蛋白(a)、血浆凝血因子VIIc的平均水平以及当前吸烟患病率方面，未发现地区间存在显著差异。
