Weijenberg M P, Feskens E J, Kromhout D
Department of Chronic Diseases and Environmental Epidemiology, National Institute of Public Health and Environmental Protection, Bilthoven, The Netherlands.
Am J Public Health. 1996 Jun;86(6):798-803. doi: 10.2105/ajph.86.6.798.
This study investigated changes in total and high-density-lipoprotein cholesterol (HDL) concentrations with age and time in elderly men.
A cohort of men born between 1900 and 1920 from the Dutch town of Zutphen was examined in 1977 and 1978 (n = 571), 1985 (n = 885), 1990 (n = 555), and 1993 (n = 345). Linear regression analysis and random-effects models were used to assess cross-sectional and longitudinal age- and time-related changes in cholesterol concentrations.
In both cross-sectional and longitudinal analyses, total cholesterol decreased by 0.04 mmol/L a year with age. The longitudinal change was observed in the entire population as well as in men who participated in all four examinations (n = 135) and in a subgroup of men who were free of common chronic diseases, were not on cholesterol-lowering medication or a prescribed diet, and rated themselves as being "healthy" (n = 64). HDL cholesterol did not change significantly with age neither on a cross-sectional nor on a longitudinal basis.
Among elderly men, total cholesterol diminishes with age both on a cross-sectional and on a longitudinal basis; HDL cholesterol does not vary with age in any way.
本研究调查了老年男性总胆固醇和高密度脂蛋白胆固醇（HDL）浓度随年龄和时间的变化。
对来自荷兰祖特芬镇1900年至1920年出生的一群男性进行了检查，时间分别为1977年和1978年（n = 571）、1985年（n = 885）、1990年（n = 555）和1993年（n = 345）。采用线性回归分析和随机效应模型来评估胆固醇浓度与年龄和时间相关的横断面及纵向变化。
在横断面和纵向分析中，总胆固醇均随年龄每年下降0.04 mmol/L。在整个人群、参加了所有四次检查的男性（n = 135）以及一组没有常见慢性病、未服用降胆固醇药物或规定饮食且自认为“健康”的男性亚组（n = 64）中均观察到了这种纵向变化。HDL胆固醇在横断面和纵向上均未随年龄发生显著变化。
在老年男性中，总胆固醇在横断面和纵向上均随年龄降低；HDL胆固醇在任何方面均不随年龄变化。
