Heckmann J M, Eastman R, Handler L, Wright M, Owen P
Neurology Unit, Groote Schuur Hospital, Cape, South Africa.
AJNR Am J Neuroradiol. 1993 Sep-Oct;14(5):1157-9.
The radiologic evolution of Leigh disease is documented with sequential brain MR in the acute phase of the illness, at 3 weeks, and at 3 months. High-signal-intensity lesions seen on T2-weighted images in the first week resolved by 3 months, whereas new lesions appear during the chronic stage. Putamenal involvement is not a pathognomonic radiologic finding. Brain stem tegmentum, particularly the mesencephalon, is characteristically involved on MR in the early and late phases of the illness.
通过在疾病急性期、3周和3个月时对大脑进行连续的磁共振成像（MR），记录了Leigh病的放射学演变过程。在第一周T2加权图像上可见的高信号强度病变在3个月时消失，而新的病变在慢性期出现。壳核受累并非特异性的放射学表现。在疾病的早期和晚期，脑干被盖部，尤其是中脑，在磁共振成像上具有特征性受累表现。
