Morishita S, Sugimoto C, Shoji M, Hirai Y, Oguni Y, Ito C, Higuchi M, Sakanashi M
Research Laboratories, Kyushin Pharmaceutical Co., Ltd., Tokyo, Japan.
Am J Chin Med. 1993;21(2):139-49. doi: 10.1142/S0192415X93000170.
The pharmacological effects of the toad venom-containing drug "kyushin" on aconitine- and thyroxine-induced arrhythmia in guinea pigs, on the conduction system in Langendorff preparations of rabbit hearts and on the autonomic nervous system in cats were studied. "kyushin" significantly inhibited the aconitine-induced arrhythmia after intraduodenal administration (i.d.) with 80 mg/kg, and the thyroxine-induced arrhythmia with 40 mg/kg i.d. Although "kyushin" itself did not affect the conduction system with 30 mg/ml of the maximal concentration being able to be prepared, bufalin and cinobufagin as constituents of toad venom produced inhibition with 0.3 mg/ml and 1 mg/ml, respectively. The decrease in heart rate induced by electrical stimulation to the parasympathetic nerve (vagus nerve) was potentiated by "kyushin" at 30 mg/kg i.d. The anti-arrhythmic effects of "kyushin" may be attributable to both possible inhibitory effect on the conduction system and potentiating effect on the parasympathetic nervous system.
研究了含蟾蜍毒液的药物“救心”对豚鼠乌头碱和甲状腺素诱发心律失常的药理作用、对兔心脏Langendorff标本传导系统的作用以及对猫自主神经系统的作用。“救心”以80mg/kg十二指肠内给药（i.d.）可显著抑制乌头碱诱发的心律失常，以40mg/kg i.d.可抑制甲状腺素诱发的心律失常。尽管“救心”本身在能配制的最大浓度30mg/ml时不影响传导系统，但蟾蜍毒液成分蟾毒灵和华蟾毒精分别在0.3mg/ml和1mg/ml时产生抑制作用。“救心”以30mg/kg i.d.可增强电刺激副交感神经（迷走神经）引起的心率降低。“救心”的抗心律失常作用可能归因于对传导系统的可能抑制作用和对副交感神经系统的增强作用。
