Morishita S, Shoji M, Oguni Y, Ito C, Higuchi M, Sakanashi M
Research Laboratories, Kyushin Pharmaceutical Co., Ltd., Tokyo, Japan.
Am J Chin Med. 1992;20(3-4):245-56. doi: 10.1142/S0192415X92000254.
The cardiotonic and arrhythmogenic effects, and the excitatory effect on respiration of "Kyushin," a drug containing toad venom, were studied in comparison with those of digoxin. In anesthetized rabbits, the maximum rate of rise of left ventricular systolic pressure (max dP/dt) was measured as an index of cardiotonic effect, and the respiratory flow was measured as an index of respiratory function. Intraduodenal (i.d.) administration of 80 mg/kg "Kyushin" produced a cardiotonic effect and an excitatory effect on respiration, but i.d. administration of 16 mg/kg digoxin produced only a cardiotonic effect, and conversely inhibited respiration. In anesthetized open-chest guinea pigs, myocardial contractile force was measured as an index of cardiotonic effect and the arrhythmogenic effect was evaluated from the appearance of arrhythmic myocardial contraction. By i.d. administration of a 20% ethanol suspension or solution, "Kyushin" and digoxin showed a cardiotonic activity with doses higher than 40 mg/kg and 0.25 mg/kg, respectively. The arrhythmogenic doses of "Kyushin" and digoxin by i.d. administration were 2560 mg/kg and 2 mg/kg, respectively, suggesting that the safety margin of "Kyushin" is broader than that of digoxin.
研究了含蟾蜍毒液的药物“救心”的强心、致心律失常作用以及对呼吸的兴奋作用，并与地高辛进行了比较。在麻醉兔中，测量左心室收缩压的最大上升速率（最大dP/dt）作为强心作用指标，测量呼吸流量作为呼吸功能指标。十二指肠内（i.d.）给予80mg/kg“救心”产生强心作用和对呼吸的兴奋作用，但十二指肠内给予16mg/kg地高辛仅产生强心作用，反而抑制呼吸。在麻醉的开胸豚鼠中，测量心肌收缩力作为强心作用指标，并根据心律失常性心肌收缩的出现评估致心律失常作用。通过十二指肠内给予20%乙醇悬浮液或溶液，“救心”和地高辛分别在剂量高于40mg/kg和0.25mg/kg时显示出强心活性。十二指肠内给予“救心”和地高辛的致心律失常剂量分别为2560mg/kg和2mg/kg，表明“救心”的安全范围比地高辛更宽。
