Shoji M, Oguni Y, Sato H, Morishita S, Ito C, Higuchi M, Sakanashi M
Research Laboratories, Kyushin Pharmaceutical Co., Ltd., Tokyo, Japan.
Am J Chin Med. 1993;21(1):17-31. doi: 10.1142/S0192415X93000042.
A study was conducted on the pharmacological actions of the toad venom-containing drug "Kyushin" (KY-2 and KY-R) on urinary volume and electrolytes excretion, regional blood flow, renal artery blood flow and carrageenin-induced hind-paw edema. In rabbits, KY-2 and KY-R significantly increased urinary volume after intravenous administration of 8 mg/kg. In guinea pigs, KY-2 and KY-R produced a significant increase in urinary volume after intraduodenal administration (i.d.) of 80 mg/kg. In guinea pigs treated with propranolol, KY-2 at 20 and 40 mg/kg p.o. and KY-R at 40 mg/kg p.o. increased urinary volume. At 40 mg/kg i.d. both KY-2 and KY-R produced an increase in regional blood flow, as determined by the hydrogen gas clearance method, of the brain areas including the amygdaloid nucleus, but did not affect regional blood flow in liver, kidney and skeletal muscle, or renal artery blood flow. In rats, carrageenin-induced hind-paw edema was inhibited by KY-2 or KY-R at 600 mg/kg p.o.
对含蟾蜍毒液的药物“救心”（KY - 2和KY - R）在尿量和电解质排泄、局部血流量、肾动脉血流量以及角叉菜胶诱导的后爪水肿方面的药理作用进行了一项研究。在兔子中，静脉注射8毫克/千克的KY - 2和KY - R后显著增加尿量。在豚鼠中，十二指肠内给药（i.d.）80毫克/千克的KY - 2和KY - R后尿量显著增加。在用普萘洛尔治疗的豚鼠中，口服20和40毫克/千克的KY - 2以及口服40毫克/千克的KY - R增加了尿量。十二指肠内给药40毫克/千克时，KY - 2和KY - R均使包括杏仁核在内的脑区局部血流量（通过氢气清除法测定）增加，但不影响肝脏、肾脏和骨骼肌的局部血流量或肾动脉血流量。在大鼠中，口服600毫克/千克的KY - 2或KY - R可抑制角叉菜胶诱导的后爪水肿。
