Taylor W R, Forrester J S, Magnusson P, Takano T, Chatterjee K, Swan H J
Am J Cardiol. 1976 Oct;38(4):469-73. doi: 10.1016/0002-9149(76)90465-3.
The hemodynamic effects of nitroglycerin absorbed transcutaneously from an ointment base were determined in 10 patients with chronic congestive heart failure (9 with ischemic heart disease and 1 with cardiomyopathy). The response was characterized by a decrease in pulmonary capillary wedge pressure from an average of 30 to 19 mm Hg, and an increase in cardiac index from 1.7 to 2.2 liter/min per m2, with concomitant decreases in systemic and pulmonary vascular resistance and an increase in venous capacitance. Mean arterial pressure decreased from 85 to 80 mm Hg, and heart rate remained unchanged. The hemodynamic effects persisted for 3 to 6 hours. These results indicate that nitroglycerin ointment is a hemodynamically potent vasodilating agent with potential value in the therapy of congestive heart failure.
对10例慢性充血性心力衰竭患者（9例缺血性心脏病患者和1例心肌病患者）测定了从软膏基质经皮吸收的硝酸甘油的血流动力学效应。其反应的特征为肺毛细血管楔压从平均30 mmHg降至19 mmHg，心脏指数从1.7升/分钟每平方米增至2.2升/分钟每平方米，同时体循环和肺循环血管阻力降低，静脉容量增加。平均动脉压从85 mmHg降至80 mmHg，心率保持不变。血流动力学效应持续3至6小时。这些结果表明硝酸甘油软膏是一种血流动力学作用较强的血管扩张剂，在充血性心力衰竭治疗中具有潜在价值。
