硝酸甘油软膏的持续血流动力学作用。
Sustained haemodynamic action of nitroglycerin ointment.
作者信息
Meister S G, Engel T R, Guiha N, Furr C M, Feitosa G S, Hart K, Frankl W S
出版信息
Br Heart J. 1976 Oct;38(10):1031-6. doi: 10.1136/hrt.38.10.1031.
Intravenous vasodilators have been shown to improve the haemodynamic status of patients in congestive heart failure. However, neither intravenous nor sublingual preparations are suitable for chronic administration or use in ambulatory patients. In this study, nitroglycerin ointment bas administered to 11 patients in congestive heart failure. Mean pulmonary wedge and arterial pressures, as well as systemic blood pressures and heart rate were then monitored for 2 to 5 hours and compared with baseline values. Pulmonary wedge and arterial pressures, as well as systemic systolic arterial pressure, decreased significantly at 15 minutes after application and remained depressed for up to 5 hours. Systemic diastolic pressures fell significantly at 30 minutes and also remained significantly reduced for up to 5 hours. Thus, nitroglycerin ointment may be suitable for chronic vasodilator therapy of congestive heart failure.
静脉血管扩张剂已被证明可改善充血性心力衰竭患者的血流动力学状态。然而，静脉制剂和舌下制剂均不适用于长期给药或门诊患者使用。在本研究中，对11例充血性心力衰竭患者使用了硝酸甘油软膏。随后监测平均肺楔压和动脉压以及全身血压和心率2至5小时，并与基线值进行比较。用药后15分钟，肺楔压和动脉压以及全身收缩压显著下降，并持续降低长达5小时。全身舒张压在30分钟时显著下降，也持续显著降低长达5小时。因此，硝酸甘油软膏可能适用于充血性心力衰竭的长期血管扩张治疗。
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