Garnica A D
Ann Clin Lab Sci. 1976 Sep-Oct;6(5):446-54.
Protein hydrolysate-containing parenteral solutions have been reported to be hepatotoxic. Ten infants who were treated with a 20 percent glucose solution containing either 2.5 percent or 3.25 percent protein hydrolysate are reviewed. Their gestational ages were 30 to 40 weeks and births weights 1000 to 35000 g. Serum glutamate-oxaloacetate transaminase (GOT), glutamate-pyruvate transaminase (GPT), leucine amino peptidase (LAP) and bilirubin were measured serially. Serum amino acids were measured and consistently demonstrated decreased levels of isoleucine and increased aspartic acid, glutamic acid, serine, proline, glycine, alanine, threonine and lysine. The amino acid imbalances were associated with transaminase elevations in eight infants. Serum bilirubin levels increased in six patients and LAP in four. Liver biopsies from three patients showed minimal to moderate hepatic parenchymal disease with cholestasis.
据报道，含蛋白质水解物的肠外营养液具有肝毒性。本文回顾了10例接受含2.5%或3.25%蛋白质水解物的20%葡萄糖溶液治疗的婴儿。他们的胎龄为30至40周，出生体重为1000至3500g。连续测量血清谷草转氨酶（GOT）、谷丙转氨酶（GPT）、亮氨酸氨肽酶（LAP）和胆红素。测量血清氨基酸，结果一致显示异亮氨酸水平降低，天冬氨酸、谷氨酸、丝氨酸、脯氨酸、甘氨酸、丙氨酸、苏氨酸和赖氨酸水平升高。8例婴儿的氨基酸失衡与转氨酶升高有关。6例患者血清胆红素水平升高，4例患者LAP升高。3例患者的肝活检显示有轻度至中度肝实质疾病伴胆汁淤积。
