Roberge R J, Martin T G, Schneider S M
Department of Medicine, University of Pittsburgh Medical Center, Pennsylvania.
Ann Emerg Med. 1993 Dec;22(12):1911-5. doi: 10.1016/s0196-0644(05)80422-6.
A 23-year-old woman with an acute-on-chronic lithium overdose received multiple oral doses of sodium polystyrene sulfonate totaling 150 g over a 24-hour period. During the 33 hours after the institution of therapy, the serum lithium level decreased from 4.20 to 0.68 mEq/L. The calculated serum lithium elimination half-life of 12 hours is significantly shorter than that previously noted in other similar overdoses, and the patient suffered no adverse effects of therapy. Multiple-dose sodium polystyrene sulfonate may be useful in lowering the serum lithium level of select patients with acute lithium overdoses but is not a substitute for hemodialysis in severely ill patients.
一名23岁慢性锂中毒急性发作的女性在24小时内多次口服聚苯乙烯磺酸钠，总量达150克。在开始治疗后的33小时内，血清锂水平从4.20毫当量/升降至0.68毫当量/升。计算得出的血清锂消除半衰期为12小时，明显短于此前其他类似过量中毒情况中所记录的半衰期，且该患者未出现治疗的不良反应。多次剂量的聚苯乙烯磺酸钠可能有助于降低某些急性锂过量患者的血清锂水平，但对于重症患者而言，它并不能替代血液透析。
