Linakis J G, Hull K M, Lacouture P G, Lockhart G R, Lewander W J, Maher T J
Department of Pediatrics, Rhode Island Hospital, Providence 02903, USA.
Acad Emerg Med. 1997 Mar;4(3):175-8. doi: 10.1111/j.1553-2712.1997.tb03736.x.
To determine whether multiple doses of sodium polystyrene sulfonate (SPS) enhance the elimination of IV-administered lithium (Li).
The study was a placebo-controlled, investigator-unblinded, murine trial of multiple doses of SPS on serum Li concentrations. Seventy-five male CD-1 mice were given IV pretreatment with LiCl (125 mg/ kg) followed by gavage treatments with SPS (5 g/kg/dose) 20, 40, 90, 150, and 210 minutes after LiCl (experimental group) or deionized water at equivalent times (control group). Subgroups of each treatment group were sacrificed at 1, 2, 4, and 6 hours after LiCl administration and blood was collected for Li analysis.
Statistical analyses indicated that the SPS group had lower serum Li concentrations overall than did the control animals. This difference was apparent at the 2-, 4-, and 6-hour time points.
In this murine model, repetitive doses of orogastric SPS enhanced the elimination of parenterally administered Li.
确定多次剂量的聚苯乙烯磺酸钠（SPS）是否能增强静脉注射锂（Li）的清除。
本研究是一项安慰剂对照、研究者非盲法的小鼠试验，观察多次剂量的SPS对血清锂浓度的影响。75只雄性CD-1小鼠静脉注射氯化锂（125mg/kg）进行预处理，随后在注射氯化锂后20、40、90、150和210分钟经口灌胃给予SPS（5g/kg/剂量）（实验组），或在相同时间给予去离子水（对照组）。在注射氯化锂后1、2、4和6小时处死各治疗组的亚组小鼠，采集血液进行锂分析。
统计分析表明，SPS组的血清锂浓度总体低于对照动物。这种差异在2、4和6小时时间点明显。
在该小鼠模型中，经口重复给予SPS可增强肠道外给予锂的清除。
