Agut J, Lopez G-Coviella I, Ortiz J A, Wurtman R J
Department of Brain & Cognitive Sciences, Massachusetts Institute of Technology, Cambridge 02139.
Ann N Y Acad Sci. 1993 Sep 24;695:318-20. doi: 10.1111/j.1749-6632.1993.tb23075.x.
Exogenous cytidine 5'diphosphocholine (CDP-choline) is completely metabolized to circulating cytidine and choline. Both compounds enter the brain and can be used in phosphatidylcholine (PC) synthesis via the Kennedy (CDP-choline) cycle. We administered oral CDP-choline to 12 month-old rats (500 mg/kg/day) for 21, 42, or 90 days to determine whether this treatment would alter brain levels of PC and the other structural phospholipids, phosphatidylserine (PS) and phosphatidylethanolamine (PE). After 42 days, brain PC levels increased significantly (p < 0.01) by 23.3%; after 90 days PC increased by 30% (p < 0.01), PS by 37.2% (p < 0.01), and PE by 13% (not significant). The ratios of each of the phospholipids to total membrane phospholipids were unchanged. These data demonstrate that repeated oral CDP-choline administration can increase the amounts of phospholipids in brain membranes, thus providing a rationale for using this compound in brain diseases that damage neurons.
外源性胞苷5'-二磷酸胆碱（CDP-胆碱）完全代谢为循环中的胞苷和胆碱。这两种化合物进入大脑，并可通过肯尼迪（CDP-胆碱）循环用于磷脂酰胆碱（PC）的合成。我们给12月龄大鼠口服CDP-胆碱（500毫克/千克/天），持续21、42或90天，以确定这种治疗是否会改变大脑中PC以及其他结构磷脂磷脂酰丝氨酸（PS）和磷脂酰乙醇胺（PE）的水平。42天后，大脑PC水平显著升高（p<0.01），升高了23.3%；90天后，PC升高了30%（p<0.01），PS升高了37.2%（p<0.01），PE升高了13%（无统计学意义）。每种磷脂与总膜磷脂的比例没有变化。这些数据表明，重复口服CDP-胆碱可以增加脑膜中磷脂的含量，从而为在损害神经元的脑部疾病中使用这种化合物提供了理论依据。
