Ackerstaff A H, Hilgers F J, Aaronson N K, Balm A J, van Zandwijk N
Department of Otolaryngology-Head and Neck Surgery, The Netherlands Cancer Institute, Amsterdam.
Ann Otol Rhinol Laryngol. 1993 Nov;102(11):878-83. doi: 10.1177/000348949310201111.
A prospective clinical study in 61 patients was undertaken to investigate the subjective and objective influence of a heat and moisture exchanger (HME) on the respiratory and psychosocial problems following total laryngectomy. Although statistical comparisons failed to detect significant differences between the experimental and the control groups, there was a clear trend toward improvements in respiratory and psychosocial functioning in the experimental group. Analyses of differences over time within the HME user group showed significant reductions in the incidence of coughing, the mean daily frequency of sputum production, forced expectoration, and stoma cleaning. Significant improvements were also found in shortness of breath, fatigue and malaise, sleep problems, levels of anxiety and depression, and perceived voice quality. Pulmonary function tests showed significant improvements in inspiratory flow and volume values following use of the HME. This objective improvement in inspiratory pulmonary function reflects the decrease in sputum production reported by the patients.
对61例患者进行了一项前瞻性临床研究，以调查热湿交换器（HME）对全喉切除术后呼吸及心理社会问题的主观和客观影响。尽管统计学比较未能发现实验组与对照组之间存在显著差异，但实验组在呼吸和心理社会功能方面有明显的改善趋势。对HME使用组随时间变化的差异分析显示，咳嗽发生率、每日平均咳痰频率、用力咳痰及造口清洁次数均显著降低。在呼吸急促、疲劳和不适、睡眠问题、焦虑和抑郁水平以及感知语音质量方面也有显著改善。肺功能测试显示，使用HME后吸气流量和容积值有显著改善。吸气肺功能的这种客观改善反映了患者报告的痰液分泌减少情况。
