Jansma J, Vissink A, Jongebloed W L, Retief D H, Johannes 's-Gravenmade E
Department of Oral and Maxillofacial Surgery, University Hospital Groningen, The Netherlands.
Am J Dent. 1993 Jun;6(3):130-6.
Radiation caries is a well-known indirect side effect of head and neck radiotherapy. The initiation and progression of radiation caries were studied using an in situ model. The morphology of induced carious lesions was compared with that of natural radiation caries. Both natural and induced radiation caries showed the same patterns of decay; widespread areas with porosity of enamel, crater formation with exposure of subsurface enamel, preferential dissolution of prisms with hollowing out of prism cores, loss of large parts of surface enamel and loss of full enamel coverage exposing the underlying dentin. In irradiated patients most enamel slabs were severely demineralized within 6 weeks whereas in control subject the slabs showed no significant demineralization after 12 weeks. The model may offer an excellent opportunity to study preventive fluoride regimens because of the rapid induction of radiation caries and its similarity with natural lesions.
放射性龋是头颈部放疗众所周知的间接副作用。利用原位模型研究了放射性龋的发生和发展。将诱导龋损的形态与自然放射性龋的形态进行了比较。自然和诱导的放射性龋均表现出相同的龋坏模式：釉质广泛出现孔隙、形成凹坑并暴露表层下釉质、棱柱优先溶解并使棱柱核心中空、大部分表面釉质丧失以及釉质完全覆盖丧失从而暴露下方的牙本质。在接受放疗的患者中，大多数釉质板在6周内严重脱矿，而在对照受试者中，釉质板在12周后未显示出明显脱矿。由于放射性龋的快速诱导及其与自然病变的相似性，该模型可能为研究预防性氟化物方案提供绝佳机会。
