将单磷酸阿糖腺苷通过离子导入法应用于1型单纯疱疹病毒感染的无毛小鼠皮肤。
Iontophoretic application of adenine arabinoside monophosphate to herpes simplex virus type 1-infected hairless mouse skin.
作者信息
Park N H, Gangarosa L P, Kwon B S, Hill J M
出版信息
Antimicrob Agents Chemother. 1978 Oct;14(4):605-8. doi: 10.1128/AAC.14.4.605.
Several antiviral agents were applied topically or by iontophoresis to hairless mouse skin inoculated with herpes simplex virus type 1 (HSV-1), and the chemotherapeutic effectiveness was evaluated. Topical application of iododeoxyuridine, arabinoside A, and adenine arabinoside monophosphate (ara-AMP) moderately decreased the average lesion score, number of mice with paralysis, and number of mice dying in HSV-1-infected animals. Also, the mean survival time was moderately prolonged by topical application of those antiviral agents. When ara-AMP was applied by cathodal (-) iontophoresis to the HSV-1-infected skin, the average lesion score, number of mice with paralysis, and number of mice dying were greatly decreased. Furthermore, the mean survival time of mice was highly increased by cathodal (-) iontophoresis of ara-AMP. The therapeutic efficacy of ara-AMP iontophoresis was much superior to the topical application of iododeoxyuridine, arabinoside A, and ara-AMP. These data suggest that ara-AMP iontophoresis would be the method of choice for the management of HSV-1 skin lesions in hairless mice.
将几种抗病毒药物局部应用或通过离子导入法应用于接种了1型单纯疱疹病毒（HSV-1）的无毛小鼠皮肤，并评估其化疗效果。局部应用碘脱氧尿苷、阿糖腺苷和单磷酸阿糖腺苷（ara-AMP）可适度降低HSV-1感染动物的平均病变评分、出现麻痹的小鼠数量和死亡小鼠数量。此外，局部应用这些抗病毒药物可适度延长平均存活时间。当通过阴极（-）离子导入法将ara-AMP应用于HSV-1感染的皮肤时，平均病变评分、出现麻痹的小鼠数量和死亡小鼠数量大幅降低。此外，ara-AMP的阴极（-）离子导入法可显著延长小鼠的平均存活时间。ara-AMP离子导入法的治疗效果远优于碘脱氧尿苷、阿糖腺苷和ara-AMP的局部应用。这些数据表明，ara-AMP离子导入法将是治疗无毛小鼠HSV-1皮肤损伤的首选方法。
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