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[阿糖腺苷-5'-单磷酸病毒抑制疗法下新生儿单纯疱疹病毒感染时的骨髓抑制(作者译)]

[Suppression of bone marrow in neonatal herpes simplex virus infection under virustatic therapy with adenine arabinoside-5'-monophosphate (author's transl)].

作者信息

Ebell W, Borchard F, Knoll G, von Voss H

出版信息

Klin Padiatr. 1980 Nov;192(6):582-6. doi: 10.1055/s-2008-1035647.

Abstract

The case of a generalized neonatal herpes-simplex-virus infection with lethal outcome is presented. Therapy with adenine arabinoside-5'-monophosphate (ARA AMP) was employed with a good virustatic effect. Suppression of bone marrow and a possible immunological suppression was seen at low dose level already. Therefore in newborn and prematures we suggest a cautious regimen in employing this substance, which was until now considered to have no serious side effects.

摘要

本文报告了一例新生儿全身性单纯疱疹病毒感染致死的病例。采用5'-单磷酸阿糖腺苷(ARA AMP)进行治疗,取得了良好的抑制病毒效果。在低剂量水平时就已观察到骨髓抑制和可能的免疫抑制。因此,对于新生儿和早产儿,我们建议在使用该药物时采取谨慎的方案,该药物迄今一直被认为没有严重的副作用。

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