枯草芽孢杆菌中DNA突变体的多效性、基因外抑制作用
Pleiotropic, extragenic suppression of dna mutants in Bacillus subtilis.
作者信息
Siccardi A G, Ottolenghi S, Fortunato A, Mazza G
出版信息
J Bacteriol. 1976 Oct;128(1):174-81. doi: 10.1128/jb.128.1.174-181.1976.
Abstract
Thermosensitive (dna) mutants of Bacillus subtilis defective in deoxyribonucleic acid replication can be divided into two groups on the basis of their ability to spontaneously yield secondary mutants with an HDS phenotype (thermoin-sensitivity and resistance to aryl-azo-pyrimidines) at frequencies higher than 10(-8). Such a phenotype is due to alleles at the hds locus (mapping close to cysA), which act as extragenic pleiotropic suppressors. HDS suppressibility has been used as a screening tool to identify new dna strains among uncharacterized temperature-sensitive mutants.
摘要
枯草芽孢杆菌中在脱氧核糖核酸复制方面存在缺陷的热敏（DNA）突变体，可根据其自发产生具有HDS表型（热敏感性和对芳基偶氮嘧啶的抗性）的二级突变体的能力，分为两组，其产生频率高于10^(-8)。这种表型是由hds位点（定位于靠近cysA处）的等位基因引起的，这些等位基因起基因外多效性抑制作用。HDS抑制性已被用作一种筛选工具，以从未经鉴定的温度敏感突变体中鉴定新的DNA菌株。
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