Hayhoe F G, Neuman Z
J Clin Pathol. 1976 Oct;29(10):916-22. doi: 10.1136/jcp.29.10.916.
A cytological, cytochemical, and cytometric study of plasma cells from 195 cases of multiple myeloma showed that, contrary to earlier reports, flaming cells, thesaurocytes, and intranuclear inclusions are not confined to IgA-secreting cases but are common also in IgG and Bence Jones varieties of myeloma. IgA-secreting cells are not larger, nor do they have a lower nuclear cytoplasmic ratio than other myeloma cells. On average, for a given mass of tumour, Bence-Jones, IgG, and IgA varieties of myeloma produce amounts of paraprotein in the ratio 1 to 1-6 to 2-7.
对195例多发性骨髓瘤患者的浆细胞进行的细胞学、细胞化学和细胞计量学研究表明，与早期报告相反，火焰状细胞、贮积细胞和核内包涵体并非仅限于分泌IgA的病例，在IgG和本斯·琼斯型骨髓瘤中也很常见。分泌IgA的细胞并不比其他骨髓瘤细胞更大，核质比也不更低。平均而言，对于给定质量的肿瘤，本斯·琼斯型、IgG型和IgA型骨髓瘤产生的副蛋白量之比为1:1.6:2.7。
