骨髓瘤细胞的细胞学

Cytology of myeloma cells.

作者信息

Hayhoe F G, Neuman Z

出版信息

J Clin Pathol. 1976 Oct;29(10):916-22. doi: 10.1136/jcp.29.10.916.

DOI:10.1136/jcp.29.10.916

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC476215/

Abstract

A cytological, cytochemical, and cytometric study of plasma cells from 195 cases of multiple myeloma showed that, contrary to earlier reports, flaming cells, thesaurocytes, and intranuclear inclusions are not confined to IgA-secreting cases but are common also in IgG and Bence Jones varieties of myeloma. IgA-secreting cells are not larger, nor do they have a lower nuclear cytoplasmic ratio than other myeloma cells. On average, for a given mass of tumour, Bence-Jones, IgG, and IgA varieties of myeloma produce amounts of paraprotein in the ratio 1 to 1-6 to 2-7.

摘要

对195例多发性骨髓瘤患者的浆细胞进行的细胞学、细胞化学和细胞计量学研究表明，与早期报告相反，火焰状细胞、贮积细胞和核内包涵体并非仅限于分泌IgA的病例，在IgG和本斯·琼斯型骨髓瘤中也很常见。分泌IgA的细胞并不比其他骨髓瘤细胞更大，核质比也不更低。平均而言，对于给定质量的肿瘤，本斯·琼斯型、IgG型和IgA型骨髓瘤产生的副蛋白量之比为1:1.6:2.7。

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本文引用的文献

1

Cytology and electrophoretic pattern in gamma1A (beta2A) myeloma.γ1A（β2A）骨髓瘤的细胞学与电泳图谱

Acta Med Scand. 1961 Nov;170:575-89.

2

Intranuclear inclusions in multiple myeloma and macroglobulinemia.

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The flaming cell in multiple myeloma. A light and electron microscopy study.多发性骨髓瘤中的火焰细胞。一项光镜和电镜研究。

Am J Clin Pathol. 1965 Dec;44(6):605-12. doi: 10.1093/ajcp/44.6.605.

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Growth rates and responses to treatment in human myelomatosis.人类骨髓瘤的生长速率及对治疗的反应

Br J Haematol. 1969 Jun;16(6):607-17. doi: 10.1111/j.1365-2141.1969.tb00441.x.

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Paraproteins, benign or malignant?副蛋白，良性还是恶性？

Br Med J. 1967 Sep 16;3(5567):699-704. doi: 10.1136/bmj.3.5567.699.

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Immunocytoma o' mice an' men.小鼠与人的免疫细胞瘤。

Br Med J. 1971 Apr 10;2(5753):67-72. doi: 10.1136/bmj.2.5753.67.

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