Chen Z Y
Diagnostic Department, Qingdao Medical College.
Zhonghua Xin Xue Guan Bing Za Zhi. 1993 Jun;21(3):163-4, 188.
In our study, we measured resting tissue-type plasminogen activator(t-PA) activity and resting plasminogen activator inhibitor-1 (PAI-1) activity in 15 healthy men and in 20 patients (male) with coronary heart disease in the morning and evening. Resting t-PA activity was lower (P < 0.05) in controls and was significantly lower (P < 0.001) in patients in the morning compared with that in the evening. In contrast, PAI-1 activity was significantly higher (P < 0.001) in controls and was also significantly higher (P < 0.001) in patients in the morning compared with that in the evening. t-PA activity in patients compared with that in controls was significantly lower (P < 0.05) in the morning and the evening; PAI-1 activity in patients compared with that in controls was significantly higher (P < 0.001) in the morning and the evening. However, t-PA activity was significantly lower (P < 0.05) and PAI-1 activity was significantly higher (P < 0.05) in patients with myocardial infarction compared with anginal patients in the morning. Applying this clinical phenomenon that myocardial infarction and angina have often occurred in the morning, the relationship between time of onset of myocardial infarction and circadian variation of t-PA and PAI-1 was discussed.
在我们的研究中，我们于早晨和晚上测量了15名健康男性以及20名男性冠心病患者的静息组织型纤溶酶原激活物（t-PA）活性和静息纤溶酶原激活物抑制剂-1（PAI-1）活性。与晚上相比，早晨时对照组的静息t-PA活性较低（P<0.05），而患者的静息t-PA活性显著更低（P<0.001）。相反，早晨时对照组的PAI-1活性显著更高（P<0.001），患者的PAI-1活性与晚上相比也显著更高（P<0.001）。早晨和晚上时，患者的t-PA活性与对照组相比均显著更低（P<0.05）；早晨和晚上时，患者的PAI-1活性与对照组相比均显著更高（P<0.001）。然而，早晨时，与心绞痛患者相比，心肌梗死患者的t-PA活性显著更低（P<0.05），PAI-1活性显著更高（P<0.05）。鉴于心肌梗死和心绞痛常发生在早晨这一临床现象，我们探讨了心肌梗死发病时间与t-PA和PAI-1昼夜变化之间的关系。
