Kandel A, Buzsáki G
Center for Molecular and Behavioral Neuroscience, Rutgers, State University of New Jersey, Newark 07102.
Epilepsy Res. 1993 Sep;16(1):1-9. doi: 10.1016/0920-1211(93)90033-4.
In this study we investigated the involvement of the cerebellum in high voltage spike-and-wave spindles, a rodent model of petit mal epilepsy. High voltage spindles, recorded epidurally from the sensorimotor neocortex, were correlated with single or multiple unit activity in the cerebellar cortex and deep cerebellar nuclei. The majority of neurons or neuronal groups in the cerebellum (77.9%) fired rhythmically and phase-locked with the high voltage spindles, either during the spike (43.2%; n = 41) or during the wave (34.7%; n = 33) component of the high voltage spindle. Tremor of the head and neck musculature, recorded with an accelero-meter, occurred during the high voltage spindle in approximately half of the rats. When present, rhythmic movement occurred predominantly during the wave phase of the high voltage spindle. The remaining half of the rats did not show tremor during high voltage spindles but, nevertheless, had cerebellar units that burst during the spike or wave phase of the high voltage spindle. These latter results demonstrate that phase-locked bursting of cerebellar units during high voltage spindle is independent of rhythmic movement. The findings suggest that rhythmic output from the cerebellum may contribute to the maintenance of generalized petit mal seizures.
在本研究中，我们调查了小脑在小发作癫痫的啮齿动物模型——高压棘波-慢波纺锤波中的作用。从感觉运动新皮层硬膜外记录到的高压纺锤波与小脑皮层和小脑深部核团中的单个或多个单位活动相关。小脑的大多数神经元或神经元群（77.9%）有节律地放电，并与高压纺锤波锁相，要么在高压纺锤波的棘波期（43.2%；n = 41），要么在慢波期（34.7%；n = 33）。用加速度计记录的头颈部肌肉震颤在大约一半的大鼠的高压纺锤波期间出现。当出现时，节律性运动主要发生在高压纺锤波的慢波期。其余一半的大鼠在高压纺锤波期间未出现震颤，但是，它们的小脑单位在高压纺锤波的棘波期或慢波期有爆发性活动。后一组结果表明，小脑单位在高压纺锤波期间的锁相爆发与节律性运动无关。这些发现提示，小脑的节律性输出可能有助于全身性小发作癫痫的维持。
