Vergnes M, Marescaux C, Depaulis A, Micheletti G, Warter J M
Exp Neurol. 1987 Apr;96(1):127-36. doi: 10.1016/0014-4886(87)90174-9.
In an inbred strain of Wistar rats, spontaneous spike and wave discharges (8 to 10 c/s) appeared regularly on the EEG during quiet wakefulness and were accompanied by an arrest of behavioral activity associated with vibrissal and facial myoclonia. These seizures were recorded over the entire neocortex, but predominantly in the frontoparietal cortex. Subcortical bipolar recordings in chronic preparations showed that the lateral thalamic nuclei were greatly involved in these discharges: high-voltage spike and waves always appeared either simultaneously with, or slightly before the cortical discharges. In some cases, thalamic discharges were not accompanied by cortical discharges. No discharges were recorded in medial thalamic nuclei, in the cingulate cortex, or in the hippocampus. These results confirm the thalamocortical prevalence in the development of these rats' petit mal-like seizures, with a possible driving from thalamic nuclei.
在一个近交系Wistar大鼠中，在安静觉醒期间脑电图（EEG）上会定期出现自发的棘波和慢波放电（8至10次/秒），并伴有与触须和面部肌阵挛相关的行为活动停止。这些癫痫发作在整个新皮层均有记录，但主要出现在额顶叶皮层。慢性制备中的皮层下双极记录显示，外侧丘脑核在这些放电中起很大作用：高压棘波和慢波总是与皮层放电同时出现，或略早于皮层放电。在某些情况下，丘脑放电并不伴有皮层放电。在内侧丘脑核、扣带回皮层或海马体中未记录到放电。这些结果证实了丘脑皮层在这些大鼠小发作样癫痫发展中的优势地位，丘脑核可能起到驱动作用。
