Girlanda P, Quartarone A, Sinicropi S, Nicolosi C, Messina C
Clinica Neurologica 2, University of Messina, Italy.
Mov Disord. 1996 Jan;11(1):27-31. doi: 10.1002/mds.870110107.
We studied six patients affected with blepharospasm (BSP). We injected botulinum toxin (BTX) around only one eye and saline solution around the other. Clinical rating of BSP was performed. Single fiber electromyography (SFEMG), compound motor action potential (cMAP) at the orbicularis oculi muscle by stimulation of the facial nerve, blink reflex, and blink reflex recovery curve were recorded. All clinical and electrophysiological investigations were carried out before, and 1, 2, and 4 weeks after treatment. Evidence of bilateral clinical benefit was provided. Following therapy, facial cMAP decreased bilaterally and SFEMG revealed statistically significant changes on both sides while the excitability curve of blink reflex remained unmodified. The results confirm that BTX affects merely the neuromuscular junctions. The clinical and neurophysiological effects are present on both sides also for unilateral injection probably because of toxin spreading.
我们研究了6例患有眼睑痉挛（BSP）的患者。我们仅在一只眼睛周围注射肉毒杆菌毒素（BTX），而在另一只眼睛周围注射生理盐水。对BSP进行了临床评分。记录了单纤维肌电图（SFEMG）、通过刺激面神经在眼轮匝肌处的复合运动动作电位（cMAP）、瞬目反射和瞬目反射恢复曲线。所有临床和电生理检查均在治疗前以及治疗后1周、2周和4周进行。提供了双侧临床获益的证据。治疗后，双侧面部cMAP降低，SFEMG显示两侧有统计学意义的变化，而瞬目反射的兴奋性曲线保持不变。结果证实BTX仅影响神经肌肉接头。单侧注射时，临床和神经生理效应在两侧也均存在，这可能是由于毒素扩散所致。
