[Changes in concentration of the blood serum malondialdehyde due to a one-time and long-term ethanol and acetaldehyde administration].

Changes in concentration of the rat blood serum malone dialdehyde (MDA) at separate and combined action of ethanol and acetaldehyde under conditions of their single and long-term administration have been investigated. In some series of experiments acetaldehyde and ethanol were administered together with teturame. The obtained data permit supposing that under conditions of acute ethanol intoxication an increase of the MDA concentration is caused by the acetaldehyde action. The long-term ethanol intoxication induces a significantly higher (if compared with acute intoxication) increase the MDA concentration. The results confirm the concept of the lipid peroxidation process at acute and chronic intoxication due to ethanol metabolism. Acetaldehyde is an important factor among those determining disturbances of cell biogenesis in the animal organism, causing an increase of the blood serum MDA.