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落基山斑疹热的快速确诊：皮肤组织中立克次体的鉴定

Prompt confirmation of Rocky Mountain spotted fever: identification of rickettsiae in skin tissues.

作者信息

Woodward T E, Pedersen C E, Oster C N, Bagley L R, Romberger J, Snyder M J

出版信息

J Infect Dis. 1976 Sep;134(3):297-301. doi: 10.1093/infdis/134.3.297.

DOI:10.1093/infdis/134.3.297
PMID:824374
Abstract

Rickettsia rickettsii were identifiable by the immunofluorescence technique in skin specimens obtained by biopsy on days 4 and 8 of illness from patients with Rocky Mountain spotted fever. The immunofluorescence technique is regarded as a practical means of confirming the diagnosis during the early stages of illness before positive serologic reactions can be obtained.

摘要

在落基山斑疹热患者发病第4天和第8天通过活检获取的皮肤标本中，利用免疫荧光技术可识别出立氏立克次体。免疫荧光技术被视为在获得阳性血清学反应之前疾病早期阶段确诊的实用手段。

相似文献

1
Prompt confirmation of Rocky Mountain spotted fever: identification of rickettsiae in skin tissues.落基山斑疹热的快速确诊：皮肤组织中立克次体的鉴定
J Infect Dis. 1976 Sep;134(3):297-301. doi: 10.1093/infdis/134.3.297.
2
Identification of rickettsiae in cutaneous biopsy specimens from dogs with experimental Rocky Mountain spotted fever.从患有实验性落基山斑疹热的犬皮肤活检标本中鉴定立克次体。
J Vet Intern Med. 1989 Jan-Mar;3(1):8-11.
3
Diagnosis of Rocky Mountain spotted fever by immunofluorescent identification of Rickettsia rickettsii in skin biopsy tissue.通过对皮肤活检组织中瑞氏立克次体进行免疫荧光鉴定来诊断落基山斑疹热。
J Pediatr. 1979 Jul;95(1):63-5. doi: 10.1016/s0022-3476(79)80083-9.
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[Spotted fever: isolation of Rickettsia from a skin biopsy sample].
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5
Correlation of rickettsial titers, circulating endotoxin, and clinical features in Rocky Mountain spotted fever.落基山斑疹热中立克次体滴度、循环内毒素与临床特征的相关性
Arch Intern Med. 1983 Jun;143(6):1149-51.
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Laboratory diagnosis of Rocky Mountain spotted fever by immunofluorescent demonstration of Rickettsia in Cutaneous lesions.通过免疫荧光法在皮肤病变中显示立克次体来进行落基山斑疹热的实验室诊断。
Am J Clin Pathol. 1978 Jun;69(6):619-23. doi: 10.1093/ajcp/69.6.619.
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Laboratory diagnosis of Rocky Mountain spotted fever.落基山斑疹热的实验室诊断
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Rocky Mountain spotted fever from an unexpected tick vector in Arizona.来自亚利桑那州一种意外蜱虫媒介的落基山斑疹热。
N Engl J Med. 2005 Aug 11;353(6):587-94. doi: 10.1056/NEJMoa050043.
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Evaluation of immunoperoxidase techniques to detect Rickettsia rickettsii in fixed tissue sections.评估免疫过氧化物酶技术在固定组织切片中检测立氏立克次体的效果。
Am J Clin Pathol. 1994 Jun;101(6):747-52. doi: 10.1093/ajcp/101.6.747.
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A focus of Rocky Mountain spotted fever within New York City.纽约市境内落基山斑疹热的一个疫源地。
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引用本文的文献

1
Laboratory diagnosis of rickettsioses: current approaches to diagnosis of old and new rickettsial diseases.立克次体病的实验室诊断：诊断新旧立克次体病的当前方法
J Clin Microbiol. 1997 Nov;35(11):2715-27. doi: 10.1128/jcm.35.11.2715-2727.1997.
2
Diagnosis of Mediterranean spotted fever by cultivation of Rickettsia conorii from blood and skin samples using the centrifugation-shell vial technique and by detection of R. conorii in circulating endothelial cells: a 6-year follow-up.采用离心管瓶技术从血液和皮肤样本中培养康氏立克次体以及检测循环内皮细胞中的康氏立克次体来诊断地中海斑疹热：一项6年随访研究
J Clin Microbiol. 1996 Nov;34(11):2722-7. doi: 10.1128/jcm.34.11.2722-2727.1996.
3
Rocky Mountain spotted fever following cardiac transplantation.
心脏移植后发生落基山斑疹热。
West J Med. 1993 Jun;158(6):625-8.
4
Use of a sensitive microplate enzyme-linked immunosorbent assay in a retrospective serological analysis of a laboratory population at risk to infection with typhus group rickettsiae.在一项针对有感染斑疹伤寒群立克次体风险的实验室人群的回顾性血清学分析中使用灵敏的微孔板酶联免疫吸附测定法。
J Clin Microbiol. 1980 Sep;12(3):343-50. doi: 10.1128/jcm.12.3.343-350.1980.
5
Development and characterization of high-titered, group-specific fluorescent-antibody reagents for direct identification of rickettsiae in clinical specimens.用于直接鉴定临床标本中立克次体的高滴度、群特异性荧光抗体试剂的研制与特性分析。
J Clin Microbiol. 1980 May;11(5):503-7. doi: 10.1128/jcm.11.5.503-507.1980.
6
Detection of Rickettsia rickettsii DNA in clinical specimens by using polymerase chain reaction technology.运用聚合酶链反应技术检测临床标本中的立氏立克次体DNA。
J Clin Microbiol. 1989 Dec;27(12):2866-8. doi: 10.1128/jcm.27.12.2866-2868.1989.
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Rocky Mountain spotted fever: a disease in need of microbiological concern.落基山斑疹热：一种需要微生物学关注的疾病。
Clin Microbiol Rev. 1989 Jul;2(3):227-40. doi: 10.1128/CMR.2.3.227.
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Kidney lesions in Rocky Mountain spotted fever: a light-, immunofluorescence-, and electron-microscopic study.落基山斑疹热中的肾脏病变：一项光镜、免疫荧光及电子显微镜研究。
Am J Pathol. 1979 Nov;97(2):381-92.
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Tetracyclines in unusual infections.四环素用于特殊感染
Bull N Y Acad Med. 1978 Feb;54(2):237-48.
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Identification of Rickettsia rickettsii in formalin-fixed, paraffin-embedded tissues by immunofluorescence.通过免疫荧光法在福尔马林固定、石蜡包埋组织中鉴定立氏立克次体。
J Clin Microbiol. 1978 Aug;8(2):242-5. doi: 10.1128/jcm.8.2.242-245.1978.