酿酒酵母spo13菌株单分裂减数分裂过程中染色体与酵母人工染色体的混合分离和重组。
Mixed segregation and recombination of chromosomes and YACs during single-division meiosis in spo13 strains of Saccharomyces cerevisiae.
作者信息
Hugerat Y, Simchen G
机构信息
Department of Genetics, Hebrew University of Jerusalem, Israel.
出版信息
Genetics. 1993 Oct;135(2):297-308. doi: 10.1093/genetics/135.2.297.
Abstract
Diploid yeast strains, homozygous for the mutation spo13, undergo a single-division meiosis and form dyads (two spores held together in one ascus). Dyad analysis of spo13/spo13 strains with centromere-linked markers on five different chromosomes and on a pair of human DNA YACs shows that: (a) in spo13 meiosis, chromosomes undergo mixed segregation, namely some chromosomes segregate reductionally whereas others, in the same cell, segregate equationally; (b) different chromosomes exhibit different segregation tendencies; (c) recombination between homologous chromosomes might not determine that a bivalent undergoes reductional rather than equational segregation.
摘要
对于突变体spo13纯合的二倍体酵母菌株，会进行单分裂减数分裂并形成二分体（两个孢子在一个子囊中结合在一起）。对spo13/spo13菌株进行二分体分析，这些菌株在五条不同染色体以及一对人类DNA YAC上带有与着丝粒相连的标记，结果表明：(a) 在spo13减数分裂中，染色体进行混合分离，即一些染色体进行减数分离，而在同一细胞中的其他染色体进行均等分离；(b) 不同染色体表现出不同的分离倾向；(c) 同源染色体之间的重组可能无法决定二价体进行减数分离而非均等分离。
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