The isolation and characterization of a lipopolysaccharide-specific Pseudomonas aeruginosa bacteriophage.

The isolation and some properties of a lipopolysaccharide (LPS)-specific phage isolated against Pseudomonas aeruginosa is reported. The phage, designtaed omega PLS-I, is a Bradley A type phage with a head diameter of 70 nm and a contractile tail 120 nm long. The average adsorption rate constant for omegaPLS-I is 4-48 X 10(-9) ml/min. omegaPLS-I is inactivated by purified LPS from P. aeruginosa strain 1-1A, showing a PhI50 value of 1-25 mug/ml.