Sahay R, Prangnell D R, Scott B B
Department of Medicine, County Hospital, Lincoln.
Gut. 1993 Nov;34(11):1630-1. doi: 10.1136/gut.34.11.1630.
Two patients with colitis and refractory anaemia requiring multiple transfusions are described. In one the anaemia was detected at the onset of colitis before drug treatment; in the other it started after 21 years of treatment with sulphasalazine and during an exacerbation of colitis with perianal abscess for which he had just been started receiving prednisolone, cofluampicil and metronidazole. Glomerulonephritis developed two weeks after the onset of anaemia. These findings together with a recent report of four patients with Crohn's disease and refractory anaemia suggests that the association may be more than coincidental and may be immune mediated.
本文描述了两名患有结肠炎且难治性贫血需多次输血的患者。其中一名患者在结肠炎发病时、药物治疗前就已检测出贫血；另一名患者在接受柳氮磺胺吡啶治疗21年后，且在结肠炎加重并伴有肛周脓肿发作时开始出现贫血，当时他刚开始接受泼尼松龙、氯氟苄醇和甲硝唑治疗。贫血发作两周后出现了肾小球肾炎。这些发现以及最近一篇关于四名克罗恩病合并难治性贫血患者的报告表明，这种关联可能并非巧合，可能是由免疫介导的。
