人类9号染色体长臂34.1区的高分辨率连锁图谱。
A high-resolution linkage map of human 9q34.1.
作者信息
Henske E P, Ozelius L, Gusella J F, Haines J L, Kwiatkowski D J
机构信息
Division of Experimental Medicine and Hematology-Oncology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02115.
出版信息
Genomics. 1993 Sep;17(3):587-91. doi: 10.1006/geno.1993.1376.
A map comprising 16 distinct markers with heterozygosities of 0.61-0.92 for a 10-cM region of human 9q34.1 is presented. The map incorporates four genes and has a maximum intermarker interval of 2.1 cM. Markers were analyzed in the Venezuelan reference pedigrees and all were placed uniquely in the map with a minimum likelihood of 676:1. The map should prove useful in analysis of families segregating dystonia and tuberous sclerosis, as the DYT1 and TSC1 loci map within this region.
本文展示了一张包含16个不同标记的图谱，该图谱针对人类9号染色体长臂34.1区10厘摩（cM）的区域，杂合度在0.61至0.92之间。该图谱纳入了四个基因，标记间的最大间隔为2.1厘摩。这些标记在委内瑞拉参考家系中进行了分析，所有标记都以最小676:1的似然比唯一地定位在图谱中。由于肌张力障碍1型（DYT1）和结节性硬化症1型（TSC1）基因座位于该区域内，因此该图谱在分析分离肌张力障碍和结节性硬化症的家系时应会很有用。
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