Alausa K O, Montefiore D, Akinyosoye O, Osoba A O, Sogbetun O A, Coker G O
J Trop Med Hyg. 1976 Aug;79(8):177-81.
Infections due to Ps. aeruginosa are a problem in the tropics as in other parts of the world. Over a four year period, 15 patients attending University College Hospital, Ibadan, were proved to have septicaemia due to this organism and 13 patients died rapidly as a direct result of the infection. The two patients who survived the acute episode had received immediate treatment with at least one antibiotic active against Ps. aeruginosa: a third patient, who received immediate appropriate antibiotic therapy, was already suffering from aplastic anaemia and died rapidly despite treatment. The remaining patients received inappropriate antibiotic therapy because pseudomonas infection was not suspected at the time the diagnosis of septicaemia was made. Patients most at risk appear to be the very young and those with pre-existing malignant or other conditions affecting the defence mechanisms of the body: it is suggested that routine initial management of such patients should include a blood culture, followed by immediate treatment with an antibiotic combination that includes at least one agent likely to be active against Ps. aeruginosa. The development of medical services can lead to the introduction of ophthalmic or other operations on tissues that are highly susceptible to infection before facilities are provided for the maintenance of a pathogen-free environment. Following an outbreak of eye infection after cataract extractions, carried out in an old and unsatisfactory theatre, wide-spread room contamination was demonstrated with the same strains of Ps. aeruginosa that had been responsible for the clinical infections. Chemical disinfection of the theatre floor failed to eliminate the organisms, although other experiments suggested that the drying effect of air-conditioning would be successful in this respect. The wisdom of introducing such operations before the provision of adequate facilities is seriously questioned.
铜绿假单胞菌感染在热带地区和世界其他地区一样都是个问题。在四年时间里，伊巴丹大学学院医院的15名患者被证实因该病菌引发败血症，其中13名患者因感染直接迅速死亡。在急性发作期存活下来的两名患者接受了至少一种对铜绿假单胞菌有效的抗生素的即时治疗：第三名患者接受了即时恰当的抗生素治疗，但已患有再生障碍性贫血，尽管接受了治疗仍很快死亡。其余患者接受了不恰当的抗生素治疗，因为在诊断败血症时未怀疑有假单胞菌感染。风险最高的患者似乎是非常年幼的儿童以及患有影响身体防御机制的先前恶性疾病或其他疾病的患者：建议对此类患者的常规初始处理应包括进行血培养，随后立即使用包含至少一种可能对铜绿假单胞菌有效的药物的抗生素组合进行治疗。医疗服务的发展可能会在尚未提供维持无病原体环境的设施之前，就引入对极易感染的组织进行眼科或其他手术。在一个老旧且不尽人意的手术室进行白内障摘除术后爆发眼部感染后，发现手术室广泛受到与导致临床感染的相同菌株的铜绿假单胞菌污染。对手术室地面进行化学消毒未能消除这些病菌，尽管其他实验表明空调的干燥作用在这方面可能会成功。在提供足够设施之前就开展此类手术是否明智受到了严重质疑。
