Hähnel E, Harvey J M, Joyce R, Robbins P D, Sterrett G F, Hähnel R
Hospital and University Pathology Services, Queen Elizabeth II Medical Centre, Nedlands, Australia.
Int J Cancer. 1993 Nov 11;55(5):771-4. doi: 10.1002/ijc.2910550513.
Stromelysin-3 expression was studied by Northern blotting in 222 tissue samples including primary and metastatic breast carcinoma and normal breast tissue. Uninvolved breast tissue from mastectomy specimens, normal breast tissue from reduction mammoplasties and normal lymph nodes did not contain stromelysin-3 mRNA. About 62% of primary and metastatic breast carcinomas, but only 1 of 10 in situ ductal carcinomas, expressed stromelysin-3. Stromelysin-3 mRNA was found more often in estrogen-receptor-positive carcinomas and in histological grade-1 carcinomas. There was no significant correlation between stromelysin-3 expression and other prognostic factors, including tumor size, lymph-node involvement, age of patient, vascular invasion and cathepsin-D.
通过Northern印迹法在222个组织样本中研究了基质溶解素-3的表达，这些组织样本包括原发性和转移性乳腺癌以及正常乳腺组织。乳房切除术标本中未受累的乳腺组织、乳房缩小整形术中的正常乳腺组织和正常淋巴结均未含有基质溶解素-3 mRNA。约62%的原发性和转移性乳腺癌表达基质溶解素-3，但原位导管癌中10例仅有1例表达。基质溶解素-3 mRNA在雌激素受体阳性癌和组织学1级癌中更常见。基质溶解素-3表达与其他预后因素之间无显著相关性，这些预后因素包括肿瘤大小、淋巴结受累情况、患者年龄、血管侵犯和组织蛋白酶-D。
