Mellenberg D E, Schoeppel S L
Department of Radiation Oncology, University of Michigan, Ann Arbor.
Int J Radiat Oncol Biol Phys. 1993 Nov 15;27(4):953-8. doi: 10.1016/0360-3016(93)90473-9.
A technique for treating mycosis fungoides confined to the scalp using a method known as the 4 x 4 technique is presented.
Uniform dose distribution on the scalp and acceptable "hot spots" along five match lines is accomplished by using four sets of four fields (i.e., 4 x 4) on the patient. Precise and reproducible patient and field alignment was accomplished with a solid thermoplastic mask, which is the surface on which match lines are drawn. In-vivo dosimetry (thermoluminescent dosimeters and film) are easily attached to the mask which also provides a portion of the 7 mm bolus used to shift the characteristic 6 MeV electron depth dose toward the skin surface.
In-vivo dosimetry demonstrated that single fraction match line doses are within 25% to 30% of central axis dose. Shifting these match lines to four locations reduces these "hot spots" to satisfactory levels (less than 120%). Three patients have been treated with this technique and each patient continues to have a complete clinical response at 14 to 21 months post treatment. In addition, each patient has excellent cosmetic results with no evidence of acute or chronic side effects at the match lines.
The 4 x 4 technique has proven to be useful in the treatment of mycosis fungoides confined to the scalp.
介绍一种使用所谓的4×4技术治疗局限于头皮的蕈样肉芽肿的方法。
通过在患者身上使用四组四个野(即4×4),实现头皮上均匀的剂量分布以及沿五条匹配线的可接受“热点”。使用坚固的热塑性面罩实现精确且可重复的患者和野对准,匹配线即绘制在该面罩表面。体内剂量测定(热释光剂量计和胶片)可轻松附着在面罩上,该面罩还提供了用于将特征性的6兆电子伏电子深度剂量向皮肤表面偏移的7毫米等效物的一部分。
体内剂量测定表明,单次分割匹配线剂量在中心轴剂量的25%至30%范围内。将这些匹配线移至四个位置可将这些“热点”降低至令人满意的水平(低于120%)。三名患者已接受该技术治疗,每位患者在治疗后14至21个月仍保持完全临床缓解。此外,每位患者的美容效果极佳,匹配线处无急性或慢性副作用迹象。
4×4技术已被证明可有效治疗局限于头皮的蕈样肉芽肿。