分枝杆菌、诺卡菌、棒状杆菌及厌氧棒状杆菌细胞壁的促有丝分裂活性。

Mitogenic activity of the cell walls of mycobacteria, nocardia, corynebacteria and anaerobic coryneforms.

作者信息

Azuma I, Taniyama T, Sugimura K, Aladin A, Yamamura Y

出版信息

Jpn J Microbiol. 1976 Aug;20(4):263-71. doi: 10.1111/j.1348-0421.1976.tb00987.x.

DOI:10.1111/j.1348-0421.1976.tb00987.x

Abstract

The mitogenic activity of the cell walls prepared from Mycobacterium bovis BCG, Nocardia rubra, Corynebacterium diphtheriae PW8, and four species of Propionibacterium, Corynebacterium parvum ATCC 11829, Propionibacterium acnes C7, Propionibacterium granulosum ATCC 25564 and Propionibacterium avidum ATCC 25577, were investigated. These cell walls were active as mitogens on normal spleen cells, anti-O sera-treated spleen cells, macrophage-depleted spleen cells of C57BL/6J mice and cortisone-treated thymocytes of C57BL/6J mice. It was also shown that these cell walls were mitogenic on spleen cells and macrophage-depleted spleen cells of congenitally athymic (nude) mice. The above results suggest that the cell walls investigated in this study act as mitogens on both thymus-derived lymphocytes (T-cells) and bone marrow-derived lymphocytes (B-cells).

摘要

对由牛分枝杆菌卡介苗、红色诺卡氏菌、白喉棒状杆菌PW8以及四种丙酸杆菌（短小棒状杆菌ATCC 11829、痤疮丙酸杆菌C7、颗粒丙酸杆菌ATCC 25564和嗜丙酸丙酸杆菌ATCC 25577）制备的细胞壁的促有丝分裂活性进行了研究。这些细胞壁作为促细胞分裂剂，对正常脾细胞、抗O血清处理的脾细胞、C57BL/6J小鼠的巨噬细胞耗尽的脾细胞以及C57BL/6J小鼠的可的松处理的胸腺细胞具有活性。还表明，这些细胞壁对先天性无胸腺（裸）小鼠的脾细胞和巨噬细胞耗尽的脾细胞具有促有丝分裂作用。上述结果表明，本研究中所研究的细胞壁对胸腺来源的淋巴细胞（T细胞）和骨髓来源的淋巴细胞（B细胞）均起促细胞分裂剂的作用。