Yu T J, Chu C C
Department of Surgery, Veterans General Hospitals-Taipei, Taiwan, Republic of China.
J Biomed Mater Res. 1993 Oct;27(10):1329-39. doi: 10.1002/jbm.820271013.
The objective of this study is to determine the effects of the location and concentration of synthetic absorbable yarn components in bicomponent vascular graft fabrics on their structure and properties in a controlled in vitro hydrolytic environment. Bicomponent vascular fabrics were made from Dacron and polyglycolic acid (PGA) yarns with a range of composition ratios of PGA to Dacron and a range of locations of PGA. Both woven and single jersey knit fabrics were made. These fabrics were characterized by standard textile methods and subject to in vitro hydrolytic degradation study. In vitro hydrolytic degradation study showed that the most dramatic changes in the bicomponent fabric characteristics and properties occurred 30 and 60 days of hydrolysis. This schedule coincided with the hydrolytic degradation rate of PGA absorbable sutures. In the woven (W) group, the incorporation of absorbable yarns in the weft direction (W3) of the bicomponent fabrics resulted in the velour-like, loose, and porous surface morphology of the fabric for potential subsequent tissue ingrowth, while those woven fabrics with absorbable yarns in the warp direction (W1) did not have this unique velour-like surface. In the knitted (K) group, the concentration of absorbable yarns appeared to be closely related to the observed changes in fabric properties and structure. The incorporation of absorbable yarns into knitted fabrics did not result in the same level change in fabric structure and property as woven fabrics. In both W and K groups, a minimal level of mechanical strength of the fabrics was maintained due to the remaining Dacron yarns. Structural integrity of these fabrics was retained at the end of hydrolytic degradation study. The data obtained could be used to correlate with the subsequent in vivo performance of these bicomponent vascular grafts. If correlations exist, they could be used to improve the design of future bicomponent vascular grafts for improved performance.
本研究的目的是在可控的体外水解环境中，确定双组分血管移植织物中合成可吸收纱线成分的位置和浓度对其结构和性能的影响。双组分血管织物由涤纶和聚乙醇酸（PGA）纱线制成，PGA与涤纶的组成比例不同，PGA的位置也不同。制备了机织和单面针织织物。这些织物采用标准纺织方法进行表征，并进行体外水解降解研究。体外水解降解研究表明，双组分织物的特性和性能在水解30天和60天时发生了最显著的变化。这个时间安排与PGA可吸收缝线的水解降解速率一致。在机织（W）组中，在双组分织物的纬向（W3）加入可吸收纱线，使织物表面呈现出类似天鹅绒的、疏松且多孔的形态，有利于后续组织向内生长，而在经向加入可吸收纱线的机织织物（W1）则没有这种独特的类似天鹅绒的表面。在针织（K）组中，可吸收纱线的浓度似乎与观察到的织物性能和结构变化密切相关。将可吸收纱线加入针织织物中，其织物结构和性能的变化程度与机织织物不同。在W组和K组中，由于剩余的涤纶纱线，织物保持了最低水平的机械强度。在水解降解研究结束时，这些织物的结构完整性得以保留。所获得的数据可用于与这些双组分血管移植物随后的体内性能相关联。如果存在相关性，它们可用于改进未来双组分血管移植物的设计，以提高性能。
