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Direct enantiomeric separation of cis-(+/-)diltiazem in plasma by high-performance liquid chromatography with ovomucoid column.

作者信息

Rosell G, Camacho A, Parra P

机构信息

Laboratory of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Barcelona, Spain.

出版信息

J Chromatogr. 1993 Sep 8;619(1):87-92. doi: 10.1016/0378-4347(93)80449-e.

DOI:10.1016/0378-4347(93)80449-e
PMID:8245167
Abstract

A method is proposed for the direct enantiomeric separation of cis-(+/-)diltiazem in plasma. The method is based on a commercial Ultron ES-OVM column with a mobile phase of different mixtures of ethanol-phosphate buffer. The degree of extraction of the enantiomers was more than 86%. The detection limit of the method used was 5 ng of racemic mixture on column (coefficient of variation = 13%), corresponding to 3.2 ng for cis-(+/-)diltiazem and 1.8 ng for cis-(+/-)diltiazem.

摘要

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