Sullivan D M, Ben-Yosef R, Kapp D S
Department of Radiation Oncology, Stanford University School of Medicine, CA 94305.
Int J Hyperthermia. 1993 Sep-Oct;9(5):627-43. doi: 10.3109/02656739309032052.
In the field of deep regional hyperthermia cancer therapy the Sigma 60 applicator of the BSD-2000 Hyperthermia System is one of the most widely used devices. This device employs four independent sources of radiofrequency electromagnetic energy to heat tumour sites deep within the body. The difficulty in determining the input parameters for the four sources has motivated the development of a computer-based three-dimensional (3D) treatment planning system. The Stanford 3D Hyperthermia Treatment Planning System has been in clinical use at Stanford Medical Center for the past 2 years. It utilizes a patient-specific, three-dimensional computer simulation to determine safe and effective power deposition plans. An optimization programme for the selection of the amplitudes, phases and frequency for the sources has been developed and used in the clinic. Examples of the application of the treatment planning for hyperthermia treatment of pulmonary, pelvic, and mediastinal tumours are presented. Methods for quantifying the relative effectiveness of various treatment plans are reviewed.
在深部区域热疗癌症治疗领域，BSD - 2000热疗系统的Sigma 60施源器是使用最为广泛的设备之一。该设备采用四个独立的射频电磁能源来加热身体深部的肿瘤部位。确定这四个能源输入参数的困难促使了基于计算机的三维（3D）治疗计划系统的开发。斯坦福3D热疗治疗计划系统在过去两年里一直在斯坦福医疗中心临床使用。它利用针对患者的三维计算机模拟来确定安全有效的功率沉积计划。已开发出一种用于选择能源的振幅、相位和频率的优化程序并在临床上使用。文中给出了热疗治疗肺部、盆腔和纵隔肿瘤的治疗计划应用实例。还综述了量化各种治疗计划相对有效性的方法。
