Feuer G, Kellen J A, Kovacs K
Oncology. 1976;33(1):35-9. doi: 10.1159/000225098.
The effect of oral administration of coumarin on the induction of breast tumors brought about by DMBA has been studied in female Wistar rats. Coumarin given before DMBA caused a significant dose-related suppression of the incidence of adenocarcinomas, although no histologic difference was found in the tumor between untreated and coumarin-treated rats. The growth rate, size and multiplicity were also reduced and tumor occurrence was delayed. Parallel with the suppression, hepatic drug metabolizing activity was decreased and serum prolactin level increased. Coumarin given after DMBA elicited no effect on the carcinogenic potency of DMBA. In contrast to the action on mammary tumorigenesis, coumarin provided no protection against hemopoietic and adrenocortical necrosis brought about by DMBA.
在雌性Wistar大鼠中研究了口服香豆素对二甲基苯并蒽（DMBA）诱发乳腺肿瘤的影响。在给予DMBA之前给予香豆素，可导致腺癌发生率出现显著的剂量相关抑制，尽管未处理的大鼠和经香豆素处理的大鼠的肿瘤在组织学上没有差异。肿瘤的生长速率、大小和数量也降低了，肿瘤发生延迟。与这种抑制作用同时出现的是，肝脏药物代谢活性降低，血清催乳素水平升高。在给予DMBA之后给予香豆素，对DMBA的致癌效力没有影响。与对乳腺肿瘤发生的作用相反，香豆素对DMBA引起的造血和肾上腺皮质坏死没有保护作用。
