Herholz K, Pietrzyk U, Voges J, Schröder R, Halber M, Treuer H, Sturm V, Heiss W D
Department of Stereotaxy and Functional Neurosurgery, Max-Planck-Institute for Neurological Research, Köln, Germany.
J Neurosurg. 1993 Dec;79(6):853-8. doi: 10.3171/jns.1993.79.6.0853.
To determine histological correlates of the variability of glucose consumption in astrocytomas, the authors performed positron emission tomography (PET) with 18F-2-fluoro-2-deoxy-D-glucose (FDG) and matched the PET scans three-dimensionally with computerized tomography scans obtained in a stereotactic frame before biopsy. Ten patients with astrocytomas of World Health Organization Grade 2 or 3 were studied; patients with glioblastomas, oligodendrogliomas, or oligoastrocytomas were excluded from the study to avoid any confounding effects of different cell types and necroses. In samples of pure tumor, glucose consumption correlated significantly with cell density, but not with nuclear polymorphism. It is concluded that tumor cell density is a major determinant of glucose consumption in astrocytomas. The use of PET with FDG may help to locate the highest cell density and thus improve the diagnostic yield of stereotactic biopsy.
为了确定星形细胞瘤中葡萄糖消耗变异性的组织学相关性，作者采用18F-2-氟-2-脱氧-D-葡萄糖（FDG）进行正电子发射断层扫描（PET），并在活检前将PET扫描与在立体定向框架中获得的计算机断层扫描进行三维匹配。研究了10例世界卫生组织2级或3级星形细胞瘤患者；排除了胶质母细胞瘤、少突胶质细胞瘤或少突星形细胞瘤患者，以避免不同细胞类型和坏死的任何混杂效应。在纯肿瘤样本中，葡萄糖消耗与细胞密度显著相关，但与核多态性无关。得出结论，肿瘤细胞密度是星形细胞瘤中葡萄糖消耗的主要决定因素。使用FDG进行PET检查可能有助于定位最高细胞密度，从而提高立体定向活检的诊断率。
