Wright C W, Allen D, Phillipson J D, Kirby G C, Warhurst D C, Massiot G, Le Men-Olivier L
Department of Pharmacognosy, School of Pharmacy, London, UK.
J Ethnopharmacol. 1993 Sep;40(1):41-5. doi: 10.1016/0378-8741(93)90087-l.
A review of the literature on Alstonia species indicates that evidence in support of their effectiveness in the treatment of malaria is controversial. The antiprotozoal activity of the major alkaloid present in Alstonia species, echitamine, was assessed in vitro against Plasmodium falciparum and Giardia intestinalis. Echitamine displayed little antiplasmodial activity, but two quinoline alkaloids from A. coriacea (corialstonine and corialstonidine) were found to have some activity against P. falciparum although this was approximately 10 times less than that of quinine. None of the three Alstonia alkaloids was active against G. intestinalis. These results are discussed in the context of previously published data.
对夹竹桃科鸡骨常山属植物的文献综述表明，支持其治疗疟疾有效性的证据存在争议。对鸡骨常山属植物中主要生物碱埃奇明的抗原虫活性进行了体外评估，针对恶性疟原虫和肠贾第虫。埃奇明显示出几乎没有抗疟活性，但从厚叶鸡骨常山（A. coriacea）中提取的两种喹啉生物碱（厚叶鸡骨常山碱和厚叶鸡骨常山定碱）被发现对恶性疟原虫有一定活性，尽管其活性约为奎宁的十分之一。这三种鸡骨常山属生物碱对肠贾第虫均无活性。这些结果结合先前发表的数据进行了讨论。
