Littenberg B, Moses L E
Department of Medicine, Dartmouth-Hitchcock Medical Center, Lebanon, NH 03756.
Med Decis Making. 1993 Oct-Dec;13(4):313-21. doi: 10.1177/0272989X9301300408.
Reports of diagnostic accuracy often differ. The authors present a method to summarize disparate reports that uses a logistic transformation and linear regression to produce a summary receiver operating characteristic curve. The curve is useful for summarizing a body of diagnostic accuracy literature, comparing technologies, detecting outliers, and finding the optimum operating point of the test. Examples from clinical chemistry and diagnostic radiology are provided. By extending the logic of meta-analysis to diagnostic testing, the method provides a new tool for technology assessment.
诊断准确性的报告常常存在差异。作者提出了一种汇总不同报告的方法，该方法使用逻辑变换和线性回归来生成汇总的接受者操作特征曲线。这条曲线对于汇总一系列诊断准确性文献、比较技术、检测异常值以及找到测试的最佳操作点很有用。文中给出了临床化学和诊断放射学的示例。通过将荟萃分析的逻辑扩展到诊断测试，该方法为技术评估提供了一种新工具。
